The National Under-17 side, the Black Starlets, will take on their Beninois counterparts in the WAFU Zone B U17 Championship.
The game will be played at the University of Ghana Sports stadium at 16:00GMT.
While the Black Starlets have virtually qualified for the semi-finals after their 5-1 opening game win over Ivory Coast, Benin will be looking for a win to be sure of qualifying to the semi-finals.
The Beninois lost by a lone goal to their Ivorian counterparts and a defeat to Ghana this afternoon will send them parking.
The game promises to be a crunchy encounter as the Black Starlets aim to top their group with a flawless performance.